Optimal experimental design for event‐related fMRI

Optimal experimental design for event-related fMRI.

An important challenge in the design and analysis of event-related or single-trial functional magnetic resonance imaging (fMRI) experiments is to optimize statistical efficiency, i.e., the accuracy with which the event-related hemodynamic response to different stimuli can be estimated for a given amount of imaging time. Several studies have suggested that using a fixed inter-stimulus-interval (...

Efficient Experimental Design for fMRI

This chapter begins with an overview of the various types of experimental design, before proceeding to various modelling choices, such as the use of events versus epochs. It then covers some practical issues concerning the effective temporal sampling of blood oxygenationlevel-dependent (BOLD) responses and the problem of different slice acquisition times. The final and main part of the chapter ...

Analysis of fMRI Timeseries: Linear Time-Invariant Models, Event-related fMRI and Optimal Experimental Design

A trial-based experimental design for fMRI.

An experimental design for functional MRI (fMRI) is presented whose conceptual units of analysis are behavioral trials, in contrast to blocks of trials. This type of design is referred to as a trial-based (TB) fMRI design. It is explained how TB designs can afford the ability to: (1) randomize the presentation of behavioral trials and (2) utilize intertrial variance in uncontrolled behavioral m...

Multi-objective optimal experimental designs for event-related fMRI studies

In this article, we propose an efficient approach to find optimal experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). We consider multiple objectives, including estimating the hemodynamic response function (HRF), detecting activation, circumventing psychological confounds and fulfilling customized requirements. Taking into account these goals, we formulate a ...